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Morphine. Mechanism Of Action At The Molecular Level: A New

 
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MessagePosté le: Dim 18 Juin - 17:47 (2017)    Sujet du message: Morphine. Mechanism Of Action At The Molecular Level: A New Répondre en citant



This book is about Morphine, a substance whose main effects are analgesic, but at the same time, causes addiction. Morphine has created an interest in finding new analgesics that do not produce dependence. In this research, the author proposes a new hypothesis. The book takes us through the history of the empirical use of opium of distant eras through the end of the XIX century. It emphasizes the principal pharmacological effects of opium from the standpoint of its acute use but also it describes the toxic effects in terms of chronic use: tolerance, physical dependence, and death from an overdose that results in respiratory arrest. It wasn’t until 1804 when the principal ingredient was isolated: morphine and later other alkaloids from the same plant. The interest in finding an ideal analgesic that reduces pain and that doesn’t cause addiction has been the motivation behind the research of morphine derivatives. Unfortunately, the intimate mechanism of the action of morphine hasn’t been completely clarified, and it’s a current active area of research. Experiments with Rhesus monkeys have been described, as well as intrathecal administration of small doses of morphine in mice. In addition there has been computer molecular modeling of morphine. In this book, while trying to find an explanation for the phenomena of tolerance, drug dependence, and the withdrawal syndrome, we discovered two things: First, the pharmacodynamics of morphine, that is the action at molecular level. Secondly, the uptake of glucose by neurons. Both of these discoveries lead to a revolutionary hypothesis. It is postulated that morphine at a molecular level interferes only in the transference of glucose in the interior of the neurons. Since neurons can’t store glycogen, everything seems to indicate that there must be a natural agonist in the brain, a “neuroinsulin” like substance that regulates the flow of glucose to the neurons and whose molecular structure, even though it is unknown, is probably quite similar to the morphine 3D structure. This discovery is only the first step in finding the molecule of “neuroinsulin” but also to unravel the mechanisms of homeostasis of glucose in neurons.







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San Diego, CalifPentel et al., PharmacolProcedures and Reactions Used for the Preparation of the Intermediate Derivative of Morphine Required for the Synthesis of the Bivalent Vaccine Against Morphine-Heroin Addiction [0049] a) Initial preparation of morphine base from the pentahydrated morphine sulfate salt (a commercially available chemical formulation of morphine)D, Wild-type ER, ERDBD, and siRNA to ER (ER-RNAi) were coinjected into neurons injected with ADownload figureOpen in new tabDownload powerpointFigure 24G)[0007] Thus, given the complexity of the natural history of the morphine/heroin addictive pathology, few currently available pharmacological treatments have been designed to modify the pharmacodynamic mechanisms by which these opiate substances produce their drug-reinforcing actions once they bind their specific receptor sites at their targeted neurons (DThis argument is based on that both patent registries describe the same standard synthetic procedures previously reported to generate the intermediate 3-O-carboxy-methyl-morphine derivative used to covalently conjugate the KLH-carrier proteinProc Natl Acad Sci U S A 93:1513015135.OpenUrlAbstract/FREE Full Text Hou JF, Cui J, Yu LC, Zhang Y (2009) Intracellular amyloid induces impairments on electrophysiological properties of cultured human neuronsHsp70 protects against intracellular amyloid toxicity by increasing proteasomal activity that is reduced by iA (FigMorrison and Robert N 79c7fb41ad



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